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- "An unwanted ghost of San Francisco's past has resurfaced after fifty years."
- ―Official description
Zodiac Killer is a DLC-exclusive mission in Watch Dogs 2, available only by pre-ordering the game. It features the return of the infamous Zodiac Killer, who haunted San Francisco for years. Players also receive an exclusive outfit and bonuses after completing the mission.
- Near the end of the mission, Josh states he has footage of a senator denying that he is the Zodiac Killer. This is a reference to the Ted Cruz-Zodiac meme, as some people claim that he is the Zodiac Killer, but he denies all claims. The in-game senator is also from Texas, which further implies the theory that the senator is based on Ted Cruz.
- The Zodiac Killer's character model is based on the real life Zodiac Killer's wanted poster, as well as the witness description of the outfit he was wearing when he murdered a cab driver named Paul Stine in October 1969. He also uses the real life Zodiac Killer's famous line: "This is the Zodiac speaking...".